International Circulation: When using a DEB to treat in-stent restenosis would you use just balloon dilatation or in combination with another DES?
　　Dr. Eeckhout: If you have in-stent restenosis I personally believe that if you can avoid a second layer of metal then you will be better off. The important thing when you use this kind of technology is to use it properly. I think there is some bias in the results because people do not use it clearly. You must avoid geographical miss， use a short non-slippery balloon， prepare the vessel very well， and then the DEB is just here to appose the drug against the vessel wall and not to dilate. This must be done prior to application of the DEB and try to avoid using a stent.